Research Mentor Name
Dr. Ali Awad
Research Mentor Email Address
hx1179@wayne.edu
Institution / Department
Wayne State University and Department of Internal Medicine at DMC
Document Type
Research Abstract
Research Type
clinicalresearch
Graduate Level Research
no
Abstract
Title: Maternal Cardiovascular Outcomes in Pregnancies Complicated by Pulmonary Hypertension: A Multicenter Cohort Study
Authors: Ali Eidy, BS, Aiden Tang, BS, Tarun Bomma, BS, Prit Patel, BS, Asa Smith-Villegas, BS, Ali Awad, MD
Background: Routine pregnancies exhibit a considerable amount of cardiovascular strain, which is only amplified when complicated by pulmonary hypertension (PH). Despite advances in PH treatment and therapy, there is limited data that shows the outcomes of PH on maternal cardiovascular health. This study evaluated these risks across a large, diverse cohort to better understand how PH affects maternal hemodynamics and cardiac functions.
Methods: Using the TriNetX Research Network, we identified pregnant patients aged ≥18 years from 2005–2025. PH was defined using ICD-10 codes I27.0 and I27.20–I27.29. Propensity score matching (1:1) across 23 demographic and clinical characteristics produced two balanced cohorts of 6,256 PH and non-PH pregnancies. Outcomes within three years of the index pregnancy included mortality, hospitalization, peripartum cardiomyopathy, and preeclampsia/eclampsia.
Results: PH pregnancies demonstrated substantially higher adverse cardiovascular and obstetric outcomes. Pregnancies complicated by PH had increased rates of mortality (2.3% vs 1.2%, HR 1.59, 95% CI 1.21–2.10, p=0.001), hospitalizations/emergency visits (80.1% vs 72.6%, OR 1.52, 95% CI 1.40–1.65, p< 0.001), peripartum cardiomyopathy (6.4% vs 0.6%, OR 10.7, 95% CI 7.7–14.8, p< 0.001), and pre-eclampsia/eclampsia (13.7% vs 10.0%, OR 1.43, 95% CI 1.28–1.59, p< 0.001).
Conclusion: These findings support early risk assessment, close monitoring, and multidisciplinary management, especially cardiology involvement, to improve outcomes in this high-risk population.
Disciplines
Cardiovascular Diseases | Medicine and Health Sciences
Recommended Citation
Eidy, Ali; Tang, Aiden; Bomma, Tarun; Patel, Prit; Smith-Villegas, Asa; and Awad, Ali MD, "Maternal Cardiovascular Outcomes in Pregnancies Complicated by Pulmonary Hypertension: A Multicenter Cohort Study" (2026). Medical Student Research Symposium. 501.
https://digitalcommons.wayne.edu/som_srs/501