Research Mentor Name
James Paxton
Research Mentor Email Address
jpaxton@med.wayne.edu
Institution / Department
Detroit Receiving Hospital: Department of Emergency Medicine
Document Type
Research Abstract
Research Type
basicbio
Level of Research
no
Abstract
The introduction of fluids and medications via intraosseous (IO) infusion is highly dependent upon many unique aspects of bone anatomy and physiology. Key considerations include differences in the medullary cross-sectional area between insertion sites, age- and location-dependent variation in the distribution of red and yellow bone marrow, volume and pressure capacity within the venous system, and the influence of hormones and other chemical messengers on vasomotor tone. In addition to an exploration of these concepts, this chapter will also discuss the physiologic basis for pharmacokinetic relationships reported in the prevailing literature and propose methods to optimize the use of IO infusion in the care of critically ill patients.
Disciplines
Medicine and Health Sciences
Recommended Citation
Mizerowski, Andrew and Paxton, James, "Anatomy and Physiology of Intraosseous Infusion" (2024). Medical Student Research Symposium. 361.
https://digitalcommons.wayne.edu/som_srs/361