Research Mentor Name
Dr. Eishi Asano
Research Mentor Email Address
Institution / Department
Department of Pediatrics, Children’s Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, Michigan, 48201, USA.
Level of Research
Rationale: Humans utilize executive control processes to carry out non-automatic tasks. These tasks require coordination from higher brain centers to both suppress inappropriate behaviors and initiate correct responses. The goal of this study is to generate a novel, dynamic brain atlas to visualize and understand the network dynamics underlying executive control.
Methods: We studied 547 non-epileptic intracranial electrode sites sampled from seven patients with focal epilepsy. Each patient performed two types of verbal tasks: word-reading and Stroop color-naming. Mixed model analysis compared high-gamma cortical activation prior to response onset between the word-reading and Stroop color-naming tasks. Based on mixed model analysis, we visualized the white matter connectivity between the brain regions exhibiting simultaneous high-gamma augmentation.
Results: In the Stroop color-naming task, mixed model analysis showed more high-gamma augmentation 600 to 400 ms pre-response onset in the prefrontal region (e.g., left caudal middle-frontal gyrus; p = 0.0054; figure 1 arrowhead). Conversely, in the word-reading tasks, more high-gamma augmentation was seen in the occipitotemporal region (e.g., left posterior fusiform gyrus; p = 0.0002; figure 1 arrow). Dynamic tractography in the Stroop color-naming task showed functional connectivity enhancement between prefrontal regions 500 to 400 ms pre-response onset (figure 2 arrow). On the other hand, functional connectivity in the word-reading tasks was enhanced between occipitotemporal regions from 500 ms pre-response onset to 50 ms post-response (figure 2 arrowhead).
Conclusions: Prefrontal regions were activated during tasks requiring higher executive control, whereas occipitotemporal regions supported word reading.
Medical Neurobiology | Medicine and Health Sciences | Neurology | Neurosurgery | Psychological Phenomena and Processes
Brennan, Matthew T.; Sakakura, Kazuki MD; Sonoda, Masaki MD, PhD; Luat, Aimee MD; Marupudi, Neena; Sood, Sandeep MD; and Asano, Eishi MD, PhD, "Group-based four-dimensional brain mapping of executive control" (2023). Medical Student Research Symposium. 279.
High-gamma activity relative to response onset
figure 2.png (3154 kB)
Functional connectivity enhancement relative to response onset
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