Group-based four-dimensional brain mapping of executive control

Authors

Matthew T. Brennan, Wayne State University School of Medicine, Detroit, Michigan, 48201, USAFollow
Kazuki Sakakura MD, Department of Pediatrics, Children’s Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, Michigan, 48201, USA.Follow
Masaki Sonoda MD, PhD, Department of Pediatrics, Children’s Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, Michigan, 48201, USA.Follow
Aimee Luat MD, Department of Pediatrics, Children’s Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, Michigan, 48201, USA.Follow
Neena Marupudi, Department of Neurosurgery, Children’s Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, Michigan, 48201, USA.Follow
Sandeep Sood MD, Department of Neurosurgery, Children’s Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, Michigan, 48201, USA.Follow
Eishi Asano MD, PhD, Department of Pediatrics, Children’s Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, Michigan, 48201, USA.Follow

Research Mentor Name

Dr. Eishi Asano

Research Mentor Email Address

easano@med.wayne.edu

Institution / Department

Department of Pediatrics, Children’s Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, Michigan, 48201, USA.

Document Type

Research Abstract

Research Type

clinicalresearch

Level of Research

no

Abstract

Rationale: Humans utilize executive control processes to carry out non-automatic tasks. These tasks require coordination from higher brain centers to both suppress inappropriate behaviors and initiate correct responses. The goal of this study is to generate a novel, dynamic brain atlas to visualize and understand the network dynamics underlying executive control.

Methods: We studied 547 non-epileptic intracranial electrode sites sampled from seven patients with focal epilepsy. Each patient performed two types of verbal tasks: word-reading and Stroop color-naming. Mixed model analysis compared high-gamma cortical activation prior to response onset between the word-reading and Stroop color-naming tasks. Based on mixed model analysis, we visualized the white matter connectivity between the brain regions exhibiting simultaneous high-gamma augmentation.

Results: In the Stroop color-naming task, mixed model analysis showed more high-gamma augmentation 600 to 400 ms pre-response onset in the prefrontal region (e.g., left caudal middle-frontal gyrus; p = 0.0054; figure 1 arrowhead). Conversely, in the word-reading tasks, more high-gamma augmentation was seen in the occipitotemporal region (e.g., left posterior fusiform gyrus; p = 0.0002; figure 1 arrow). Dynamic tractography in the Stroop color-naming task showed functional connectivity enhancement between prefrontal regions 500 to 400 ms pre-response onset (figure 2 arrow). On the other hand, functional connectivity in the word-reading tasks was enhanced between occipitotemporal regions from 500 ms pre-response onset to 50 ms post-response (figure 2 arrowhead).

Conclusions: Prefrontal regions were activated during tasks requiring higher executive control, whereas occipitotemporal regions supported word reading.

Disciplines

Medical Neurobiology | Medicine and Health Sciences | Neurology | Neurosurgery | Psychological Phenomena and Processes

Recommended Citation

Brennan, Matthew T.; Sakakura, Kazuki MD; Sonoda, Masaki MD, PhD; Luat, Aimee MD; Marupudi, Neena; Sood, Sandeep MD; and Asano, Eishi MD, PhD, "Group-based four-dimensional brain mapping of executive control" (2023). Medical Student Research Symposium. 279.
https://digitalcommons.wayne.edu/som_srs/279