Evaluating the Role of LVI as an Indicator for Adverse Outcomes in Patients with Upper Tract Urothelial Carcinoma and its Histological Subtypes

Authors

Ivan Rakic, Wayne State UniversityFollow
Matthew Davis, Henry Ford HealthFollow
Nicholas Corsi, Wayne State UniversityFollow
Alexander Stephens, Henry Ford HealthFollow
Chase Morrison, Wayne State UniversityFollow
Sohrab Arora, Henry Ford HealthFollow
Taylor Malchow, Wright State UniversityFollow
Akshay Sood, University of Texas MD Anderson Cancer CenterFollow
Craig Rogers, Henry Ford HealthFollow
Firas Abdollah, Henry Ford HealthFollow

Research Mentor Name

Dr. Firas Abdollah

Research Mentor Email Address

Abdoll1@hfhs.org

Institution / Department

Henry Ford Urology

Document Type

Research Abstract

Research Type

healthimprovement

Level of Research

no

Abstract

Lymphvascular invasion (LVI) is recognized as an adverse prognostic factor in many cancers. Our aim is to assess the prognostic ability of LVI in UTUC urothelial carcinoma (UC) and micropapillary urothelial carcinoma (MPUC) subtypes as a predictor of overall survival (OS) using a large North American cohort.

Our cohort included 9750 cM0 UTUC patients who underwent a radical nephroureterectomy (RNU), between 2004 and 2015, within the National Cancer Database (NCDB). The main variable of interest was LVI status, and its interaction with pathological nodal (pN) status. Kaplan-Meier curves were used to estimate the OS. Cox regression analysis tested the impact of LVI status on OS after accounting for covariates.

In patients with UC at 5-years post-RNU, the OS rates were 60.2%, 29.9%, 28.9%, and 20.8% in patient with pN0 without LVI, pN0 with LVI, pN+ without LVI, and pN+ with LVI, respectively (p

Our report is the first to examine the impact of LVI on OS in a large North American nationwide cohort. It indicates that LVI is associated with reduced OS in patients with UTUC treated surgically.

Disciplines

Female Urogenital Diseases and Pregnancy Complications | Male Urogenital Diseases | Neoplasms | Surgery | Urology

Recommended Citation

Rakic, Ivan; Davis, Matthew; Corsi, Nicholas; Stephens, Alexander; Morrison, Chase; Arora, Sohrab; Malchow, Taylor; Sood, Akshay; Rogers, Craig; and Abdollah, Firas, "Evaluating the Role of LVI as an Indicator for Adverse Outcomes in Patients with Upper Tract Urothelial Carcinoma and its Histological Subtypes" (2023). Medical Student Research Symposium. 217.
https://digitalcommons.wayne.edu/som_srs/217

Comments

Thank you Drs. Rogers, Abdollah, and all those at Henry Ford Urology, at the Vattikuti Center of Research and Education who have enabled this project to be possible and the guidance needed to execute it fully.