EVALUATION OF THE UTILITY OF LYMPH-VASCULAR INVASION AS AN INDEPENDENT PROGNOSTIC PREDICTOR OF OVERALL SURVIVAL FOR PATIENTS WITH RENAL CELL CARCINOMA THAT UNDERGO NEPHRECTOMY

Authors

Ivan Rakic, Wayne State UniversityFollow
Nikola Rakic MD, Baylor College of MedicineFollow
Nicholas Corsi, Wayne State University School of Medicine
Austin Piontkowski, Wayne State University School of Medicine
Sami Majdalani MD, Henry Ford Health SystemFollow
Akshay Sood MD, Henry Ford Health SystemFollow
Deepansh Dalela MD, Henry Ford Health SystemFollow
Sohrab Arora MD, Henry Ford Health SystemFollow
Marcus Jamil MD, Henry Ford Health SystemFollow
Craig Rogers MD, Henry Ford Health SystemFollow
Firas Abdollah MD, Henry Ford Health SystemFollow

Research Mentor Name

Dr. Firas Abdollah

Research Mentor Email Address

fabdoll1@hfhs.org

Institution / Department

Henry Ford Health System VCORE

Document Type

Research Abstract

Research Type

clinicalresearch

Level of Research

no

Abstract

Lymph-vascular invasion(LVI) is recognized as an adverse pathological feature in patients with renal cell carcinoma RCC) patients. Its impact on overall survival (OS) is not clear, and scarcely addressed in literature. Our aim was to assess the prognostic ability of LVI as a predictor of OS in RCC patients using a large, North American cohort.

We included 45,036 cM0 RCC patients from 2010-2015 who underwent partial or radial nephrectomy within the NCDB. Kaplan-Meier curves and log-rank test compared survival curves. Cox regression analysis tested the relationship between LVI and OS.

Median age was 60. Most patients had pT1 stage(70.0%), and 7.7% had LVI(LVI₁). Nodal status was pN0(14.0%), pN1(3.7%), and pNx(82.3%). Median follow-up was 38 months. At 5-years, OS was 59.8% in LVI₁ patients vs 85.1% in LVI₀patients(p

Our findings highlight the detrimental impact of LVI on OS, a novel validation of the prognostic ability of LVI in RCC patients in a nationwide cohort. We observed a synergistic impact for LVI in the presence of pN1. These patients fare worse than those who have pN1 disease without LVI. Our findings highlight an important utility that LVI can provide in deciding a patient's prognosis after nephrectomy, and further exploration should examine exactly what its role may become.

Disciplines

Medicine and Health Sciences

Recommended Citation

Rakic, Ivan; Rakic MD, Nikola; Corsi, Nicholas; Piontkowski, Austin; Majdalani MD, Sami; Sood MD, Akshay; Dalela MD, Deepansh; Arora MD, Sohrab; Jamil MD, Marcus; Rogers MD, Craig; and Abdollah MD, Firas, "EVALUATION OF THE UTILITY OF LYMPH-VASCULAR INVASION AS AN INDEPENDENT PROGNOSTIC PREDICTOR OF OVERALL SURVIVAL FOR PATIENTS WITH RENAL CELL CARCINOMA THAT UNDERGO NEPHRECTOMY" (2022). Medical Student Research Symposium. 133.
https://digitalcommons.wayne.edu/som_srs/133