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Access Type
WSU Access
Date of Award
January 2024
Degree Type
Dissertation
Degree Name
Ph.D.
Department
Psychiatry and Behavioral Neurosciences
First Advisor
Jeong-won Jeong
Abstract
Epilepsy is a highly prevalent disease which shows disproportionally higher rates of diagnosis and cognitive consequence in pediatric populations. A particularly concerning seizure type seen in a variety of neurological etiologies are epileptic spasms: stereotypically brief and repetitive seizures that are often associated with poor developmental prognosis. When epileptic spasms are refractory to pharmaceutical management, surgical procedures targeting seizure-generating tissue are an option that can be curative. This project characterizes high-frequency ictal activity from patients undergoing this surgery and defines functional and anatomical networks that constrain its propagation. Onset timing of detected signals on subdural electrodes were compared to metrics of white matter pathways revealed by diffusion MRI tractography. We found that the latency of high-frequency activity onset was associated with interictal spike timing and multiple diffusion MRI measures of direct corticocortical pathways, suggesting an anatomical framework of spasm propagation. Applications of this understanding may help refine interpretation and processing of presurgical data for improved surgical outcomes.
Recommended Citation
O'hara, Nolan, "Propagation Of Subdural Signals In Neurosurgical Patients With Epileptic Spasms" (2024). Wayne State University Dissertations. 3740.
https://digitalcommons.wayne.edu/oa_dissertations/3740