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Access Type
WSU Access
Date of Award
January 2018
Degree Type
Dissertation
Degree Name
Pharm.D./Ph.D.
Department
Chemistry
First Advisor
Matthew J. Allen
Abstract
The research described in this thesis was focused on detection of EuII and EuIII using different
modes of imaging, such as 19F-magnetic resonance imaging and photoacoustic imaging within the
context of oxygen-sensitive imaging agents. Prior to this research, EuII had been explored as a T1
shortening contrast agent for magnetic resonance imaging, but the optical properties of EuII had
never been explored within the context of an oxidation-responsive imaging agent, and a redox
responsive 19F- magnetic resonance imaging signal had not been detected in vivo.
A fluorinated EuII-containing complex was used to evaluate positive contrast intraperitoneal
until it was oxidized to the corresponding EuIII-containing complex in vivo and detected with 19F
magnetic resonance imaging. Additionally, oxidized EuIII-containing complex was detected intact
in mouse urine, which is promising for future toxicity studies and use in vivo. Two EuII-containing
complexes that absorb visible light, were detected using photoacoustic imaging until oxidized to
the EuIII-containing analogs which turns the photoacoustic signal off.
The ability to form unique images EuII/III-containing complexes as a function of oxidation state
is a powerful tool to distinguish regions of hypoxia in vivo.
Recommended Citation
Basal, Lina, "Multimodal Europium(ii)-Containing Complexes With Applications In Redox Sensing" (2018). Wayne State University Dissertations. 2010.
https://digitalcommons.wayne.edu/oa_dissertations/2010