Off-campus WSU users: To download campus access dissertations, please use the following link to log into our proxy server with your WSU access ID and password, then click the "Off-campus Download" button below.

Non-WSU users: Please talk to your librarian about requesting this dissertation through interlibrary loan.

Access Type

WSU Access

Date of Award

January 2017

Degree Type


Degree Name



Biomedical Engineering

First Advisor

Yong Xu


The fine micro-architecture of neural tissue complicates efforts to create neural interface hardware capable of high resolution input and output from neural circuitry. Microtechnology provides a unique opportunity to create neural interface hardware with efficiency and precision that is capable of utilizing multiple modalities for recording and stimulating neural activity. In this thesis work, we investigate the application of silicon-parylene hybrid micro-structures for the creation of novel microtechnology based neural interface devices capable of electrical, chemical, and optical interrogation of neural tissue activity. Specifically, we explore the creation of the following devices: 1) microstructured neural probes with microfluidic delivery for chronic suppression of tissue response, 2) integration of optics including optical fibers and waveguides into neural probes, and 3) development of a mechanically tunable microfabricated cochlear implant probe for use in rats.

Off-campus Download