Access Type
Open Access Dissertation
Date of Award
January 2015
Degree Type
Dissertation
Degree Name
Ph.D.
Department
Physiology
First Advisor
Karin Przyklenk
Abstract
Hypoxic events encountered during the perinatal period leading to pathologic decreases in fetal cerebral oxygen availability are detrimental resulting in neonatal hypoxic-ischemic encephalopathy (HIE). This work focused on the characterization of a rat model of neonatal HIE for use in the preclinical evaluation of infrared light therapy (IRL). Consistent with results from previous IRL efficacy studies using a rat model of adult global brain ischemia, IRL treatment attenuated cerebral injury resulting from hypoxia-ischemia in the neonatal rat. Thus, and perhaps most importantly, this work contributes to the development of a potential novel therapeutic approach in the management of brain injuries arising as a result of perinatal asphyxia
Recommended Citation
Reynolds, Christian Andrew, "Preclinical Evaluation Of Infrared Light Therapy In A Rat Model Of Neonatal Hypoxic-Ischemic Encephalopathy" (2015). Wayne State University Dissertations. 1294.
https://digitalcommons.wayne.edu/oa_dissertations/1294