Research posted here explores:
- Structural Biology
- Cellular Metal Homeostasis and Drug Resistance
Submissions from 2021
Lysine 53 Acetylation of Cytochrome c in Prostate Cancer: Warburg Metabolism and Evasion of Apoptosis, Viktoriia Bazylianska, Hasini A. Kalpage, Junmei Wan, Asmita Vaishnav, Gargi Mahapatra, Alice A. Turner, Dipanwita Dutta Chowdhury, Katherine Kim, Paul T. Morse, Icksoo Lee, Joseph S. Brunzelle, Lisa Polin, Prabal Subedi, Elisabeth I. Heath, Izabela Podgorski, Katrin Marcus, Brian FP Edwards, and Maik Hüttemann
Submissions from 2020
Characterization and assembly of the Pseudomonas aeruginosa aspartate transcarbamoylase-pseudo dihydroorotase complex, Chandni Patel, Asmita Vaishnav, Brian FP Edwards, and David R. Evans
Submissions from 2019
Regulation of Respiration and Apoptosis by Cytochrome c Threonine 58 Phosphorylation, Junmei Wan, Hasini A. Kalpage, Asmita Vaishnav, Jenney Liu, Icksoo Lee, Gargi Mahapatra, Alice A. Turner, Matthew P. Zurek, Qinqin Ji, Carlos T. Moraes, Maurice-Andre Recanati, Lawrence I. Grossman, Arthur R. Salomon, Brian FP Edwards, and Maik Hüttemann
Submissions from 2017
Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney: Implications for AMP Kinase, Gargi Mahapatra, Ashwathy Varughese, Qinqin Ji, Icksoo Lee, Jenney Liu, Asmita Vaishnav, Christopher Sinkler, Alexandr A. Kapralov, Carlos T. Moraes, Thomas H. Sanderson, Timothy L. Stemmler, Lawrence I. Grossman, Valerian E. Kagan, Joseph S. Brunzelle, Arthur R. Salomon, Brian FP Edwards, and Maik Hüttemann
Submissions from 2016
New Open Conformation of SMYD3 Implicates Conformational Selection and Allostery, Nicholas Spellmon, Xiaonan Sun, Wen Xue, Joshua Holcomb, Srinivas Chakravarthy, Weifeng Shang, Brian FP Edwards, Nualpun Sirinupong, Chunying Li, and Zhe Yang
Integrative genomic and transcriptomic analysis for pinpointing recurrent alterations of plant homeodomain genes and their clinical significance in breast cancer, Huimei Yu, Yuanyuan Jiang, Lanxin Liu, Wenqi Shan, Xiaofang Chu, Zhe Yang, and Zeng-Quan Yang
Submissions from 2015
Molecular Dynamics Simulation Reveals Correlated Inter-Lobe Motion in Protein Lysine Methyltransferase SMYD2, Nicholas Spellmon, Xiaonan Sun, Nualpun Sirinupong, Brian FP Edwards, Chunying Li, and Zhe Yang
Submissions from 2013
The mononuclear metal center of type-I dihydroorotase from aquifex aeolicus, Brian FP Edwards, Roshini Fernando, Philip D. Martin, Edward Grimley, Melissa Cordes, Asmita Vaishnav, Joseph S. Brunzelle, Hedeel Evans, and David R. Evans
Submissions from 2011
The prevalence of canine Leishmania infantum infection in western China detected by PCR and serological tests, Jun-Yun Wang, Yu Ha, Chun-Hua Gao, Yong Wang, Yue-Tao Yang, and Hai-Tang Chen
Submissions from 2010
Oxidation of Methane by a Biological Dicopper Centre, Ramakrishnan Balasubramanian, Stephen M. Smith, Swati Rawat, Liliya A. Yatsunyk, Timothy L. Stemmler, and Amy C. Rosenzweig
The globin gene family of the cephalochordate amphioxus: implications for chordate globin evolution, Bettina Ebner, Georgia Panopoulou, Serge N. Vinogradov, Laurent Kiger, Michael C. Marden, Thorsten Burmester, and Thomas Hankeln
NMR Assignments of a Stable Processing Intermediate of Human Frataxin, Kalyan C. Kondapalli, Krisztina Z. Bencze, Eric Dizin, James A. Cowan, and Timothy L. Stemmler
Frataxin and Mitochondrial FeS Cluster Biogenesis, Timothy L. Stemmler, Emmanuel Lesuisse, Debumar Pain, and Andrew Dancis
Resonance Assignments and Secondary Structure Predictions of the As(III) Metallochaperone ArsD in Solution, Jun Ye, Yanan He, Jack Skalicky, Barry P. Rosen, and Timothy L. Stemmler
Submissions from 2009
Self-Assembly and Disassembly of the SNARE Complex: Examined Using Circular Dichroism and Atomic Force Microscopy, Jeremy D. Cook, Won Jin Cho, Timothy L. Stemmler, and Bhanu P. Jena
Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures, Robert P. Lisak, Joyce A. Benjamins, Beverly Bealmear, Liljana Nedelkoska, Diane Studzinski, Ernest Retland, Bin Yao, and Susan Land
Submissions from 2008
A phylogenomic profile of hemerythrins, the nonheme diiron binding respiratory proteins, Xavier Bailly, Stefano Vanin, Christine Chabasse, Kenji Mizuguchi, and Serge N. Vinogradov
Structure and Dynamics of Metalloproteins in Live Cells, Jeremy D. Cook, James E. Penner-Hahn, and Timothy L. Stemmler
The Caenorhabditis globin gene family reveals extensive nematode-specific radiation and diversification, David Hoogewijs, Sasha De Henau, Sylvia Dewilde, Luc Moens, Marjolein Couvreur, Gaetan Borgonie, Serge N. Vinogradov, Scott W. Roy, and Jacques R. Vanfleteren
Evolution of Metal(loid) Binding Sites in Transcriptional Regulators, Efrén Ordóñez, Saravanamuthu Thiyagarajan, Jeremy D. Cook, Timothy L. Stemmler, José A. Gil., Luís M. Mateos, and Barry P. Rosen
A Cytosolic Iron Chaperone that Delivers Iron to Ferritin, Haifeng Shi, Krisztina Z. Bencze, Timothy L. Stemmler, and Caroline C. Philpott
Association of Copper to Riboflavin Binding Protein; Characterization by EPR and XAS, Shelia R. Smith, Krisztina Z. Bencze, Kristen Wasiukanis, Timothy L. Stemmler, and Marilee Benore-Parsons
DroID: the Drosophila Interactions Database, a comprehensive resource for annotated gene and protein interactions, Jingkai Yu, Svetlana Pacifico, Guozhen Liu, and Russell L. Finley Jr
Submissions from 2007
Human Frataxin: Iron and Ferrochelatase Binding Surface, Krisztina Z. Bencze, Taejin Yoon, César Millán-Pacheco, Patrick B. Bradley, Nina Pastor, J. A. Cowan, and Timothy L. Stemmler
Wide diversity in structure and expression profiles among members of the Caenorhabditis elegans globin protein family, David Hoogewijs, Eva Geuens, Sylvia Dewilde, Andy Vierstraete, Luc Moens, Serge Vinogradov, and Jacques R. Vanfleteren
Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for glial and neural-related molecules in central nervous system mixed glial cell cultures: neurotrophins, growth factors and structural proteins, Robert P. Lisak, Joyce A. Benjamins, Beverly Bealmear, Liljana Nedelkoska, Bin Yao, Susan Land, and Diane Studzinski
A proteome-wide protein interaction map for Campylobacter jejuni, Jodi R. Parrish, Jingkai Yu, Guozhen Liu, Julie A. Hines, Jason E. Chan, Bernie A. Mangiola, Huamei Zhang, Svetlana Pacifico, Farshad Fotouhi, Victor J. DiRita, Trey Ideker, Phillip Andrews, and Russell L. Finley Jr
Characterization and Structure of a Zn2+ and [2Fe-2S]-containing Copper Chaperone from Archaeoglobus Fulgidus, Matthew H. Sazinsky, Benjamin LeMoine, Maria Orofino, Roman Davydov, Krisztina Z. Bencze, Timothy L. Stemmler, Brian M. Hoffman, José M. Argüello, and Amy C. Rosenzweig
Submissions from 2006
The Structure and Function of Frataxin, Krisztina Z. Bencze, Kalyan C. Kondapalli, Jeremy D. Cook, Stephen McMahon, César Millán-Pacheco, Nina Pastor, and Timothy L. Stemmler
Three-dimensional Structure of the Bacterial Cell Wall Peptidoglycan, Samy O. Meroueh, Krisztina Z. Bencze, Dusan Hesek, Mijoon Lee, Timothy L. Stemmler, and Shahriar Mobashery
A phylogenomic profile of globins, Serge N. Vinogradov, David Hoogewijs, Xavier Bailly, Raúl Arredondo-Peter, Julian Gough, Sylvia Dewilde, Luc Moens, and Jacques R. Vanfleteren
Submissions from 2004
The Importance of a Critical Protonation State and the Fate of the Catalytic Steps in Class A β-Lactamases and Penicillin-binding Proteins, Dasantila Golemi-Kotra, Samy O. Meroueh, Choonkeun Kim, Sergei B. Vakulenko, Alexey Bulychev, Ann J. Stemmler, Timothy L. Stemmler, and Shahriar Mobashery
Integrated allosteric regulation in the S. cerevisiae carbamylphosphate synthetase Рaspartate transcarbamylase multifunctional protein, Val̩rie Serre, Bernadette Penverne, Jean-Luc Souciet, Serge Potier, Hedeel Guy, David Evans, Patrick Vicart, and Guy Herv̩
A Drosophila protein-interaction map centered on cell-cycle regulators, Clement A. Stanyon, Guozhen Liu, Bernardo A. Mangiola, Nishi Patel, Loic Giot, Bing Kuang, Huamei Zhang, Jinhui Zhong, and Russell L. Finley Jr
Submissions from 2003
Purified Particulate Methane Monooxygenase From Methylococcus Capsulatus (Bath) is a Dimer With Both Mononuclear Copper and a Copper-containing Cluster, Raquel L. Lieberman, Deepak B. Shrestha, Peter E. Doan, Brian M. Hoffman, Timothy L. Stemmler, and Amy C. Rosenzweig
Submissions from 1995
The Crystal Structure of Recombinant Human Neutrophil-activating Peptide-2 (M6L) at 1.9-Å Resolution, Michael G. Malkowski, Jean Yang Wu, Jerome B. Lazar, Paul H. Johnson, and Brian FP Edwards
Submissions from 1992
Structural changes that accompany the reduced catalytic efficiency of two semisynthetic ribonuclease analogs, V. Srini J. de Mel, Philip D. Martin, Marilynn S. Doscher, and Brian FP Edwards
The structure of residues 7-16 of the Aɑ-chain of human fibrinogen bound to bovine thrombin at 2.3 Å resolution, Philip D. Martin, William Robertson, Dusan Turk, Robert Huber, Wolfram Bode, and Brian FP Edwards
The Structure of a Complex of Bovine ɑ-Thrombin and Recombinant Hirudin at 2.8-Å Resolution, Jacqueline Vitali, Philip D. Martin, Michael G. Malkowski, William D. Robertson, Jerome B. Lazar, Richard C. Winant, Paul H. Johnson, and Brian FP Edwards
Submissions from 1989
The Three-dimensional Structure of Bovine Platelet Factor 4 at 3.0-Å Resolution, Robert St. Charles, Daniel A. Walz, and Brian FP Edwards
Submissions from 1987
The refined crystal structure of a fully active semisynthetic ribonuclease at 1.8 Å resolution, Philip D. Martin, Marilynn S. Doscher, and Brian FP Edwards