Human Biology Open Access Pre-Prints

Document Type

Article

Anticipated Volume

95

Anticipated Issue

4

Abstract

Glucose 6-Phosphate Dehydrogenase (G6PD) deficiency is the most prevalent enzyme deficiency of human erythrocytes affecting more than 500 million people globally. G6PD deficiency is the most common hemolytic X-linked genetic disease, which shows a higher prevalence rate in the malarial endemic population. This review paper aims to examine the overall frequency of G6PD deficiency in the Indian population using systemic review, with a special emphasis on the differential prevalence rate across the populations. PubMed, Google Scholar, and Science Direct databases were searched to examine the scientific studies focusing on the prevalence of G6PD deficiency amongst the Indian populations. A total of 52 studies were selected after following several inclusion-exclusion criteria, which comprised a total of 66,470 participants. It is observed that the G6PD deficiency is higher among males than females, which is expected as this enzymopathy is caused by inherited mutations of the X-linked gene G6PD. Moreover, the disorder is considerably greater among the populations that prefer consanguineal and endogamous marriages, like Parsi, Muslim, and tribal populations as compared to the non-tribal and caste populations. Hence, culturally based marriage practices may help to explain differences in the frequency of this hemolytic genetic disorder among Indian populations.

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