Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency among Indian Populations: A Systematic Review

Document Type

Article

Authors

Sudipta Ghosh, North Eastern Hill UniversityFollow

Open Access Pre-Print

https://digitalcommons.wayne.edu/humbiol_preprints/227/

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most prevalent enzyme deficiency of human erythrocytes, affecting more than 500 million people globally. G6PD deficiency is the most common hemolytic X-linked genetic disease, which shows a higher prevalence rate in the malaria-endemic population. This review essay aims to examine the overall frequency of G6PD deficiency in the Indian population using systemic review, with a special emphasis on the differential prevalence rate across populations. PubMed, Google Scholar, and ScienceDirect databases were searched to examine the scientific studies focusing on the prevalence of G6PD deficiency among Indian populations. A total of 32 studies were selected after following several inclusion-exclusion criteria, which comprised a total of 115,300 participants. It is observed that the G6PD deficiency is higher among males than females, which is expected as this enzymopathy is caused by inherited mutations of the X-linked gene G6PD. Moreover, the disorder is considerably greater among populations that prefer consanguineal and endogamous marriages, such as Parsi, Muslim, and tribal populations, as compared with nontribal and caste populations. Hence, culturally based marriage practices may help to explain differences in the frequency of this hemolytic genetic disorder among Indian populations.

Recommended Citation

Ghosh, Sudipta (2023) "Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency among Indian Populations: A Systematic Review," Human Biology: Vol. 95: Iss. 4, Article 3.
Available at: https://digitalcommons.wayne.edu/humbiol/vol95/iss4/3