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Document Type

Article

Laura S. Jurado Medina, Instituto Multidiciplinario de Biología Celular (IMBICE), CONICET-CIC-Universidad Nacional de La Plata, La Plata, ArgentinaFollow
Paula B. Paz Sepúlveda, Instituto Multidiciplinario de Biología Celular (IMBICE), CONICET-CIC-Universidad Nacional de La Plata, La Plata, ArgentinaFollow
Virginia Ramallo, Centro Nacional Patagónico, CONICET, Puerto Madryn, ArgentinaFollow
Camila Sala, Instituto Multidiciplinario de Biología Celular (IMBICE), CONICET-CIC-Universidad Nacional de La Plata, La Plata, ArgentinaFollow
Julieta Beltramo, Instituto Multidisciplinario Biología Celular (IMBICE),CONICET-CIC-Universidad Nacional de La Plata, La Plata, Argentina, Laboratorio de Análisis Comparativo de ADN, Suprema Corte de Justicia de la Provincia de Buenos Aires, La Plata, ArgentinaFollow
Marisol Schwab, Instituto Multidisciplinario Biología Celular (IMBICE),CONICET-CIC-Universidad Nacional de La Plata, La Plata, ArgentinaFollow
Josefina M. B. Motti, Laboratorio de Ecología Evolutiva Humana, Núcleo de Estudios Interdisciplinarios de Poblaciones Humanas de Patagonia Austral– Facultad de Ciencias Sociales, Universidad Nacional del Centro de la Provincia de Buenos Aires, Quequén, ArgentinaFollow
María Rita Santos, Instituto Multidisciplinario Biología Celular (IMBICE),CONICET-CIC-Universidad Nacional de La Plata, La Plata, ArgentinaFollow
Mariela V. Cuello, Instituto Multidisciplinario Biología Celular (IMBICE),CONICET-CIC-Universidad Nacional de La Plata, La Plata, ArgentinaFollow
Susana Salceda, División Antropología, Facultad de Ciencias Naturales y Museo (FCNyM), UNLP, La Plata, ArgentinaFollow
José E. Dipierri, Instituto de Biología de la Altura, Facultad de Humanidades y Ciencias Sociales, Universidad Nacional de Jujuy (UNJu), San Salvador de Jujuy, ArgentinaFollow
Emma L. Alfaro Gómez, Instituto de Biología de la Altura, Facultad de Humanidades y Ciencias Sociales, Universidad Nacional de Jujuy (UNJu), San Salvador de Jujuy, Argentina, Instituto de Ecorregiones Andinas, UNJu, San Salvador de Jujuy, ArgentinaFollow
Marina Muzzio, Instituto Multidisciplinario Biología Celular (IMBICE),CONICET-CIC-Universidad Nacional de La Plata, La Plata, Argentina, FCNyM, UNLP, La Plata, ArgentinaFollow
Claudio M. Bravi, Instituto Multidisciplinario Biología Celular (IMBICE),CONICET-CIC-Universidad Nacional de La Plata, La Plata, Argentina, FCNyM, UNLP, La Plata, ArgentinaFollow
Graciela Bailliet, Instituto Multidisciplinario Biología Celular (IMBICE),CONICET-CIC-Universidad Nacional de La Plata, La Plata, ArgentinaFollow

Open Access Pre-Print

Abstract

Haplogroup Q originated in Eurasia around 30,000 years ago. It is present in Y-chromosomes from Asia and Europe at rather low frequencies. Since America is undoubtedly one of the continents where this haplogroup is highly represented, it has been defined as one of the founding haplogroups. Its M3 clade has been early described as the most frequent, with pan-American representation. However, it was also possible to find several other haplogroup Q clades at low frequencies. Numerous mutations have been described for haplogroup Q, allowing analysis of its variability and assignment of its geographic origin. We have analyzed 442 samples of unrelated men from Argentina and Paraguay belonging to haplogroup Q; here we report specifically on 27 Q (xM3) lineages. We tested 3 single-nucleotide polymorphisms (SNPs) by amplified product-length polymorphism (APLP) analysis, 3 SNPs for restriction fragment length polymorphism (RFLP) analysis, 15 SNPs by Sanger sequencing, and 17 short tandem repeats (STRs). Our approach allowed us to identify five subhaplogroups. Q-M3 and Q-CTS2730/Z780 are undoubtedly autochthonous lineages and represent the most frequent subhaplogroups, with significant representation in self-defined aboriginal populations, and their autochthonous status has been previously described. The aim of present work was to identify the continental origin of the remaining Q lineages. Thus, we analyzed the STR haplotypes for the samples and compared them with haplotypes described by other authors for the rest of the world. Even when haplogroup Q lineages have been extensively studied in America, some of them could have their origin in post-Columbian human migration from Europe and Middle East.

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