A critical appraisal and clinical application of: DeVore GR, Owens O, Kase N. Use of intravenous Premarin in the treatment of dysfunctional uterine bleeding--a double-blind randomized control study. Obstet Gynecol. 1982 Mar;59(3):285-91.
This appraisal identifies significant statistical irregularities in the study. A reworking of the study's statistics leads to a conclusion different from that put forth by the authors of this paper: intravenous estrogen therapy is not, in fact, significantly more effective compared to placebo therapy for the cessation of acute abnormal uterine bleeding.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Simmer S. Intravenous estrogen is not proven effective for abnormal uterine bleeding: guidelines are based on flawed evidence. Clin. Res. Pract. 2015;1(1):eP1003. doi: 10.22237/crp/1423243521