Researchers in an article appearing in Nature used asymptotic (i.e., large sample) chi-square tests in analyzing haplotypes of Y chromosomes using the polymerase chain reaction applied to genomic DNA from male Israeli, North American, and British Jews. The use of classical methods for analyzing extremely sparse contingency tables is frequently done, but with the advent of statistical software capable of conducting exact tests, researchers should certainly cease relying on outdated methods for small sample analyses. A reanalysis was conducted using modern statistical methods. Results and implications for using exact tests are discussed.
Sawilowsky, S. S. (2011). Statistical re-analysis of Jewish priests’ and non-priests’ haplotypes using exact methods. Sage Open. doi: 10.1177/2158244011413475, 1-3.