Research Mentor Name
Dr. Anita Patel
Research Mentor Email Address
Institution / Department
Henry Ford Hospital, Transplant Institute
Level of Research
Post-transplant lymphoproliferative disorder (PTLD) is a serious complication occurring in 1-3% of adult renal transplant recipients (RTR). We present a case series of 16 RTR who demonstrate a variety of PTLD manifestations.
63% of RTR received rATG induction and 38% Basiliximab. Maintenance immunosuppression post-transplantation was Prednisone, Tacrolimus, and Mycophenolate Mofetil.
Average time from transplantation to PTLD diagnosis was 96.8 months (
Immunosuppression was discontinued in all RTR at diagnosis except Prednisone. Treatment was chemotherapy alone or in combination with radiation, resection, or salvage therapy; complications included Tumor Lysis Syndrome and infections. 56% of RTR developed renal insufficiency.
5 RTR (31%) achieved complete remission with a functioning graft. PTLD mortality rate was 63%; 9 RTR died with a functioning graft. Mortality with Basiliximab induction was 83% and 55% with rATG induction. T-cell PTLD had a 100% mortality while B-cell PTLD had a 54% mortality. EBV- PTLD had a higher mortality rate (88%) than EBV + (38%) PTLD. Patients died between
PTLD with T-cell characterization, EBV negative status, and bone marrow and lymph node involvement demonstrated an increased mortality rate. PTLD has a myriad of manifestations and should be considered as a differential diagnosis in patients presenting with post-transplant lesions.
Medicine and Health Sciences
Patil, Rujuta, "Heterogenous Manifestations of Post Renal Transplant Lymphoma" (2021). Medical Student Research Symposium. 95.