Research Mentor Name

James H. Paxton MD

Research Mentor Email Address

Institution / Department

Wayne State University School of Medicine, Department of Emergency Medicine

Document Type

Research Abstract

Research Type



The cardiovascular health of those infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a major role in rates of hospitalization, mortality risk, and rates of mechanical ventilation. In patients with COVID-19, acute myocardial injury and history of cardiovascular disease are both independently established risk factors for poor patient prognosis. In addition to myocardial injury, numerous acute cardiovascular manifestations of COVID-19 disease have been identified. Previous work on this topic typically focused either upon a general description of the acute cardiovascular manifestations and sequalae of COVID-19, or upon broad-based clinical outcomes associated with COVID-19 in patients with history of cardiovascular and/or metabolic disease. However, the role of pre-existing cardiovascular and metabolic disease in predicting the development and severity of COVID-19-related cardiovascular complications remains unclear. We queried our institutional COVID-19 patient registry, extracting data on all patients who were tested for the presence of SARS-CoV-2 and myocardial injury from 3 March 2020 – 30 July 2020. We identified a total of 5,451 patients from our institutional COVID-19 registry who met our criteria, including 734 (13.5%) subjects ultimately confirmed to be COVID-19 positive, and 4,717 subjects confirmed to be COVID-19 negative. Those with a prior history of cardiovascular disease can have increased frequency of cardiovascular manifestations. Cardiovascular events in COVID-19 include acute myocardial injury, myocardial infarction, myocarditis, pericarditis, electrocardiogram abnormalities, acute thrombosis, and acute heart failure. Identifying underlying cardiovascular disease and evidence of myocardial injury may predict which patients should be prioritized or potentially require more aggressive management and treatment strategies.


Cardiology | Critical Care | Emergency Medicine | Infectious Disease | Medicine and Health Sciences | Virus Diseases


The authors would like to acknowledge the WSU Research Registry team for their tireless work collecting this data. We appreciate the literature recommendations by Cindy Nguyen, MD Candidate Class of 2023. Special thank you to Dr. Phillip Levy, MD, MPH for his leadership and innovation during these times.