Research Mentor Name

Dr. Allen Kadado

Research Mentor Email Address

Institution / Department

Henry Ford Hospital Department of Orthopaedic Surgery

Document Type

Research Abstract

Research Type


Level of Research



Total Knee Arthroplasty: Opioid-Free Analgesia in a Patient with Opioid-Induced Hyperalgesia


Case: Controlling pain in total knee arthroplasty (TKA) is important but can be complex. We present a case of a 59-year-old female with opioid-induced hyperalgesia who was referred for left knee pain and end-stage tricompartmental degenerative joint disease after failure of conservative management. We outline an approach to control postoperative pain in patients undergoing TKA who have severe opioid contraindications.

Conclusion: TKA and physical rehabilitation with a 2 year follow up period was accomplished using a multimodal non-opioid approach including a combination of gabapentin, acetaminophen, ketorolac, meloxicam, methocarbamol, a tunneled femoral nerve catheter, and peri-articular cocktail injection.

Key terms: Total knee arthroplasty, Opioid-free analgesia, Opioid induced hyperalgesia


Medicine and Health Sciences