Research Mentor Name
E. M. Haacke
Research Mentor Email Address
Institution / Department
Wayne State University Department of Radiology
Level of Research
Introduction: Our project evaluates the presence of and changes in susceptibility and volume of ring lesions (RLs) over a two-year time period in a series of relapsing remitting MS (RRMS) subjects, and identifies and quantifies any other parameters that correlated with EDSS score.
Methods: All subjects went through 3T MR imaging at baseline and 41 subjects underwent a maximum of two follow-up scans. The imaging protocol included T2 fluid attenuated inversion recovery (FLAIR), T1-weighted imaging acquired pre and post contrast, T2-weighted turbo spin-echo (T2 TSE) and susceptibility weighted imaging (SWI) sequences, all collected in a transverse mode. SWI, FLAIR, T1- and T2-weighted images were co-registered to verify the agreement of ring lesions across all modalities. The mean and peak susceptibilities of RLs on QSM data, lesion volume on FLAIR, RL volume on T2-weighted, and inner-/outer-diameters and absolute intensity value of RLs on T2-weighted data were recorded at all available time points.
Results: Quantity of ring lesions had a positive correlation with EDSS, yet lesion volume showed no such relationship. Measurements of both the entire annular ring and its section with peak susceptibility on QSM remained constant over time. On the other hand, the FLAIR lesion volume was positively correlated with EDSS.
Conclusions: This work does a comprehensive analysis of ring lesions by evaluating FLAIR, QSM and T2 data across 43 patients and over multiple time points. Since several parameters regarding RL characteristics having remained relatively constant, lesion evolution at the ring periphery may be a very slow process.
Medicine and Health Sciences
White, Rebecca; Coffman, Chad; Subramanian, Karthik; Buch, Sagar; and Haacke, E. Mark, "Quantitative Susceptibility Mapping of Ring Lesions in Relapsing Remitting Multiple Sclerosis" (2021). Medical Student Research Symposium. 105.