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Access Type
WSU Access
Date of Award
January 2023
Degree Type
Thesis
Degree Name
M.S.
Department
Molecular Biology and Genetics
First Advisor
Lawrence I. Grossman
Abstract
Biological function requires synchronous activity of many complex signaling pathways and regulatory systems: exemplifying the intersection of these complex systems is the mitochondria. The core of mitochondrial function is the Electron Transport Chain, a set of four multi-protein complexes whose proton-pumping and electron shuttling activities play a critical role in ATP production, and whose dysfunction is linked to several forms of metabolic and neuropathic disease. In this review, we compile and examine current understanding of how these complexes interact, impact, and regulate one another, collectively dubbed “intercomplex regulation.” We will discuss common mechanisms of intercomplex regulation across different cellular contexts, their impact on mitochondrial function, metabolism, and disease, as well as current hypotheses and future directions in research for this complex aspect of ETC function.
Recommended Citation
Petitpas, Marissa Lynne, "Intercomplex Regulation In The Electron Transport Chain: Complexes And Their Complexities" (2023). Wayne State University Theses. 908.
https://digitalcommons.wayne.edu/oa_theses/908