Access Type

Open Access Embargo

Date of Award

January 2019

Degree Type

Thesis

Degree Name

M.S.

Department

Immunology and Microbiology

First Advisor

Kang Chen

Abstract

Immunoglobulin D is a mysterious protein that has largely been overlooked since its discovery. It is uniquely distinct from all the other antibody classes in: expression, induction, structure and function. Within the last few years IgD has made its way back into the spotlight and novel functions of the protein have been discovered. These recent discoveries have provided the necessary information for us to uncover an additional and important function of IgD during pregnancy. It is a long-held belief among scientists that during pregnancy the only antibody class that can cross the placenta is IgG, however our data shows that this common place ideology is not correct. We find that IgD is fully capable of crossing the placenta and that vaccine-specific IgD induced by maternal vaccination undergoes placental transfer to the fetus.

Available for download on Friday, July 10, 2020

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