Open Access Thesis
Date of Award
Arun K. Iyer
Redox-responsive cerium oxide nanoparticles (CNPs) can play a versatile role in cancer therapy due to their ability to induce oxidative stress under proper pH conditions. Hyaluronic acid micelles with a high affinity to CD44 receptor which achieved more cytotoxicity towards cancer cells. The polymer-coated CNPs and HA-SMA-TPGS-CDF nanomicelles were developed for cancer therapy. The results showed that the toxicity of CNPs in tumor cells was mediated by the pro-oxidant property of CNPs under relative low pH conditions (pH~6.5) of the tumor microenvironment whereas CNPs play a (cytoprotective) anti-oxidant role, scavenging reactive oxygen species and reducing oxidative stress under normal pH conditions or pH~7.4). HA-SMA-TPGS-CDF nanomicelles held promising effective and potentially deliver approach to for intracellular delivery of 3,4-difluorobenzylidene diferuloylmethane due to higher accumulation and more cytotoxicity in cancers. Next, we will fabricate a combined nanodelivery structure having cerium oxide nanoparticles and HA-SMA-TPGS copolymer for the treatment of cancers, warranting further investigations.
Wang, Zhaoxian, "Redox Responsive Cerium Oxide Nanoparticles And Cd44 Targeted Nanomicelles For Selective Cancer Therapy" (2017). Wayne State University Theses. 592.