Open Access Thesis
Date of Award
Olivia M. Merkel
In this thesis, delivery systems for siRNA delivery are introduced with special attention to non-viral vectors. Many successful vectors used in vivo were reviewed. Our work focused on the effect of different architectures of oligospermine polmers on their suitability for siRNA delivery in lung cancer cells. Different archituctures showed different polyplex structures and variable transfection efficiencies. Moreover, we presented a review on nanoimprint lithography techniques with an outlook on possible biological applications in the field of gene and drug delivery.
Elsayed, Maha, "Oligospermines For Non-Viral Sirna Delivery" (2013). Wayne State University Theses. 296.