Open Access Thesis
Date of Award
Nutrition and Food Science
Ahmad R. Heydari
EFFECT OF FOLATE DEFICIENCY AND AGING ON mTOR SIGNALING NETWORK IN THE LIVER OF DNA POLYMERASE B HAPLOINSUFFICIENT MICE
Advisor: Dr. Ahmad R. Heydari
Major: Nutrition and Food Science
Degree: Masters of Science
The interaction between the dietary nutrients and the human genome causes some alterations in the molecular pathways that could significantly impact the development of cancer. The main approach to such concerns is to closely observe how the diet modifies the gene expressions that control several cellular processes in the human body. Folate deficiency (FD) has established an important role in modulating the base excision repair homeostasis altering the development of tumors and cancer. We anticipate that age and FD may have exerted an anti-cancer protective role in DNA polymerase B haploinsufficient (B-pol+/-) mice that are treated with a carcinogen. We hypothesize that dietary folate restriction alters mTOR signaling network in the liver to provide protection against cancer in B-pol +/- young and old mice that have been treated with a carcinogen.
Arrabi, Amanda Lynn, "Effect Of Folate Deficiency And Aging On Mtor Signaling Network In The Liver Of Dna Polymerase B Haploinsufficient Mice" (2013). Wayne State University Theses. 258.