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Access Type
WSU Access
Date of Award
January 2023
Degree Type
Dissertation
Degree Name
Ph.D.
Department
Chemistry
First Advisor
Jeremy Kodanko
Abstract
This dissertation explores innovative chemical methodologies for biological and environmental applications. The first part involves synthesizing Ru(II) complexes with acetylacetone ligands and evaluating their cytotoxicity against cancer cells. The complexes show promising selectivity against cancer cells over normal cells. Next, Ru complexes with para-substituted triphenylphosphine ligands are synthesized and characterized. Photolysis studies demonstrate their photoactivity and potential for photochemotherapy. Furthermore, two new tris-heteroleptic Ru(II) complexes with triphenylphosphine coordination are synthesized and evaluated for photochemotherapeutic applications, which exhibit enhanced cytotoxicity upon blue light irradiation. The second part includes the design and synthesis of a novel Ni(II) chelator SG-20. SG-20 shows high selectivity for Ni(II) as compared to other first row transition metal ions. Additionally, a sustainable approach using semi-synthetic proteins for metal ion recovery is also presented. The approach includes modification of myoglobin with the chelator SG-20, which resulted in high affinity and selectivity for Ni and Cu ions. The modified protein can efficiently capture valuable metals from non-traditional sources like Coal Fly Ash.
Recommended Citation
Gupta, Sayak, "Development Of Novel Chemical Tools For Biological And Enviornmental Applications" (2023). Wayne State University Dissertations. 3925.
https://digitalcommons.wayne.edu/oa_dissertations/3925