Access Type
Open Access Embargo
Date of Award
January 2023
Degree Type
Dissertation
Degree Name
Ph.D.
Department
Anatomy and Cell Biology
First Advisor
Elizabeth Berger
Abstract
Tβ4, a naturally occurring 43-amino acid protein, has been found to promote wound healing and reduce corneal inflammation. Topical Tβ4 as a therapeutic agent in conjunction with ciprofloxacin improves the outcome of Pseudomonas aeruginosa-induced keratitis by regulating the cellular functions of PMNs and MΦs and enhancing the production of SPMs. Understanding the mechanisms of Tβ4 provides valuable insights and novel therapeutic potential for resolving disease pathogenesis not only in the cornea but also in other infectious and immune-regulated inflammatory conditions.
Recommended Citation
Wang, Yuxin, "Mechanistic Insights Into The Therapeutic Potential Of Adjunctive Thymosin Beta-4 Treatment In Pseudomonas Aeruginosa-Induced Keratitis" (2023). Wayne State University Dissertations. 3897.
https://digitalcommons.wayne.edu/oa_dissertations/3897