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Access Type
WSU Access
Date of Award
January 2023
Degree Type
Dissertation
Degree Name
Ph.D.
Department
Immunology and Microbiology
First Advisor
Yuan He
Abstract
The innate immune system serves as the first line of defense against invading pathogens. Therefore it is essential that it is able to recognize and respond to a wide variety of danger signals, such as DAMPs and PAMPs. One of the most prolific methods the innate immune system uses to achieve this is through numerous pattern recognition receptors that upon detecting a danger signal initiate the formation of an intracellular multi-protein complex called an inflammasome, which facilitates the processing and release of cytokines from the cell to conduct the immune response. Many of these PRRs and/or their mechanisms of action remain uncharacterized. Additionally, there are still PRRs that form inflammasomes which have yet to be elucidated. In this dissertation we report the discovery that NLRP10, a protein previously thought to inhibit inflammasome formation, to be a PRR that can cause inflammasome formation. In this study we show that NLRP10 interacts with components of the inflammasome and catalyzes their nucleation and subsequent inflammasome assembly. These results suggest that NLRP10 may be implicated in contributing to inflammatory diseases by directly inducing inflammation.
Recommended Citation
Kelley, Nathan J., "Characterization Of The Novel Nlrp10 Inflammasome" (2023). Wayne State University Dissertations. 3858.
https://digitalcommons.wayne.edu/oa_dissertations/3858