Open Access Dissertation
Date of Award
Chemical Engineering and Materials Science
This dissertation focuses on the applications of zwitterionic polymer materials in drug delivery. In one project, zwitterionic polymer was used to construct micelle surfactants. The zwitterionic micelles were found to have an ultralow critical micelle concentration (CMC). Potential mechanism for zwitterionic micelles achieving the ultralow CMC property has been studied. Based on the ultralow CMC feature, zwitterionic micelles were used to prepare a formulation of commercial antitumor drug docetaxel, and the resulting formulation showed excellent antitumor performance. In another project, zwitterionic polymer was used to modify protein drug insulin via conjugation reaction. Compared with current protein modification methods, such as PEGylation, zwitterionic polymer conjugation drastically improved the pharmacological activity without compromising the bioactivity of insulin.
Lu, Yang, "Zwitterionic Polymer For Drug Delivery Applications" (2018). Wayne State University Dissertations. 2046.