Access Type

Open Access Dissertation

Date of Award

January 2018

Degree Type


Degree Name



Industrial and Manufacturing Engineering

First Advisor

Kenneth R. Chelst


Venous Thromboembolism (VTE) is a deadly disease and is considered as one of the top reasons for avoidable hospital deaths in the United States and around the world. Patients who survive this disease often must face life-long complications such as Post-thrombotic syndrome (PTS), Chronic thromboembolic pulmonary hypertension (CTPH), etc. Therefore, it is important to monitor and reduce the number of VTE instances in hospitals. This study shows how Electronic Health Records (EHRs) can be utilized to achieve this goal.

First, a new near real-time VTE harm measurement model was developed. Not only the developed model can deliver near real-time results, but also it can outperform the existing PSI12 measurement model that uses administrative data (sensitivity 84% vs. 38% and NPV 99% vs. 95%).

In the next step, Padua VTE risk assessment model was developed inside the EHR to deliver real-time VTE risk assessment. Retrospective data analysis was also performed to show how another risk assessment model (IMPROVE) can be developed inside EHR. Analysis were completed to show and compare the effectiveness of each model.

Finally, the results of utilizing the developed models are presented in terms of contributions to savings for the health system as well as the number of lives saved.