Access Type

Open Access Dissertation

Date of Award

January 2017

Degree Type


Degree Name



Biomedical Engineering

First Advisor

Zhifeng Kou


Mild traumatic brain injury (mTBI) accounts for over one million emergency visits in the United States each year. While most mTBI patients have normal findings in clinical neuroimaging, alterations in brain structure and functional connectivity have frequently been reported. In this study, we investigated the large-scale brain structural and functional connectivity using diffusion MRI and resting-state fMRI data. Data from 40 mTBI patients was acquired at the acute stage (within 24 hrs after injury). 35 patients returned for data acquisition at a follow-up (4-6 weeks after injury). Data was also collected from a cohort of 58 healthy subjects, 36 of whom returned for data acquisition at the second time point, 4-6 weeks later. All data was collected at Wayne State University, Detroit, Michigan, USA. We also evaluated the relationship between functional connectivity findings at the acute stage and neurocognitive symptoms at follow up to assess the feasibility of using neuroimaging data to predict neurocognitive complications after mTBI. Moreover, we developed the connectivity domain, a new analysis method which can potentially improve reproducibility and ability to compare findings across datasets.