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Coping with the diagnosis and treatment for cancer is one of the most difficult things a person or family may face. In children it is not only difficult, but also is a traumatic experience that can create negative behavioral and psychological reactions to treatments, and can even affect the long-term survival and quality of life of the child. Through a creative research program funded by Wayne State University’s President’s Research Enhancement Program, a collaborative team of faculty from the Karmanos Cancer Institute, the School of Medicine’s department of family medicine and public health sciences, and the departments of theatre and art in the College of Fine, Performing and Communication Arts are designing new ways to use creative expression to reduce anxiety of children and their parents during distressing cancer treatments.