The ordinary least squares (OLS) estimates in the regression model are efficient when the disturbances have mean zero, constant variance, and are uncorrelated. In problems concerning time series, it is often the case that the disturbances are correlated. Using computer simulations, the robustness of various estimators are considered, including estimated generalized least squares. It was found that if the disturbance structure is autoregressive and the dependent variable is nonstochastic and linear or quadratic, the OLS performs nearly as well as its competitors. For other forms of the dependent variable, rules of thumb are presented to guide practitioners in the choice of estimators.