Composite endpoints are a popular outcome in controlled studies. However, the required sample size is not easily obtained due to the assortment of outcomes, correlations between them and the way in which the composite is constructed. Data simulations are required. A macro is developed that enables sample size and power estimation.
Brown, P. M., & Ezekowitz, J. A. (2017). Power and Sample Size Estimation for Nonparametric Composite Endpoints: Practical Implementation using Data Simulations. Journal of Modern Applied Statistical Methods, 16(2), 215-230. doi: 10.22237/jmasm/1509495120