Y-Chromosome Haplogroups in the Bosnian-Herzegovinian Population Based on 23 Y-STR Loci

Document Type

Article

Authors

Serkan Doğan, Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and HerzegovinaFollow
Adna Ašić, Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and HerzegovinaFollow
Gulsen Doğan, Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and HerzegovinaFollow
Larisa Besic, Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and HerzegovinaFollow
Damir Marjanovic, Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and HerzegovinaFollow

Open Access Pre-Print

http://digitalcommons.wayne.edu/humbiol_preprints/98/

Abstract

In a study of the Bosnian-Herzegovinian (B&H) population, Y-chromosome marker frequencies for 100 individuals, generated using the PowerPlex Y23 kit, were used to perform Y-chromosome haplogroup assignment via Whit Athey’s Haplogroup Predictor. This algorithm determines Y-chromosome haplogroups from Y-chromosome short tandem repeat (Y-STR) data using a Bayesian probability-based approach. The most frequent haplogroup appeared to be I2a, with a prevalence of 49%, followed by R1a and E1b1b, each accounting for 17% of all haplogroups within the population. Remaining haplogroups were J2a (5%), I1 (4%), R1b (4%), J2b (2%), G2a (1%), and N (1%). These results confijirm previously published preliminary B&H population data published over 10 years ago, especially the prediction about the B&H population being a part of the Western Balkan area, which served as the Last Glacial Maximum refuge for the Paleolithic human European population. Furthermore, the results corroborate the hypothesis that this area was a signifijicant stopping point on the “Middle East–Europe highway” during the Neolithic farmer migrations. Finally, since these results are almost completely in accordance with previously published data on B&H and neighboring populations generated by Y-chromosome single nucleotide polymorphism analysis, it can be concluded that in silico analysis of Y-STRs is a reliable method for approximation of the Y-chromosome haplogroup diversity of an examined population.

Recommended Citation

Doğan, Serkan; Ašić, Adna; Doğan, Gulsen; Besic, Larisa; and Marjanovic, Damir (2016) "Y-Chromosome Haplogroups in the Bosnian-Herzegovinian Population Based on 23 Y-STR Loci," Human Biology: Vol. 88: Iss. 3, Article 2.
Available at: https://digitalcommons.wayne.edu/humbiol/vol88/iss3/2