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Document Type

Article

Raul A. Bastarrachea, Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245–0549.
Jack W. Kent Jr., Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245–0549.
Guadalupe Rozada, Instituto Nacional de Perinatología, Mexico City, Mexico.
Shelley A. Cole, Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245–0549.
Juan C. López-Alvarenga, Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245–0549.
Celia Aradillas, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
Olga Brito-Zurita, Instituto Mexicano del Seguro Social, Ciudad Obregón, Sonora, Mexico.
Ricardo M. Cerda-Flores, División de Genética, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, Mexico.
Emma Ibarra-Costilla, División de Genética, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, Mexico.
Esther Gallegos, Facultad de Enfermeria, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.
Hugo Laviada-Molina, Facultad de Medicina, Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico.
Victor Hernandez-Escalante, Facultad de Medicina, Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico.
Juan Rosas, Centro de Especialidades Médicas, Celaya, Guanajuato, Mexico.
Anselmo Machado, Instituto Mexicano del Seguro Social, Ciudad Obregón, Sonora, Mexico.
Felipe Vadillo, Instituto Nacional de Perinatología, Mexico City, Mexico.
Manuel Ramos, Facultad de Medicina, Universidad Juárez del Estado de Durango, Durango, Durango, Mexico.
Brissia Lazalde, Facultad de Medicina, Universidad Juárez del Estado de Durango, Durango, Durango, Mexico.
Jesus Santa-Olalla, Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico.
Jean W. Maccluer, Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245–0549.
Anthony G. Comuzzie, Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245–0549.

Abstract

Cardiovascular disease (CVD) is a major cause of mortality in the Republic of Mexico, and metabolic syndrome, a complex of CVD risk factors, is increasingly prevalent. To date, however, there have been few studies of the genetic epidemiology of metabolic syndrome in Mexico. As a first step in implementing the GEMM Family Study, a large, multicenter collaborative study, we recruited 375 individuals in 21 extended families, without ascertainment on disease, at 9 medical institutions across Mexico. Participants were measured for anthropometric (stature, weight, waist circumference) and hemodynamic (blood pressure, heart rate) phenotypes; glucose, cholesterol, and triglyceride levels were measured in fasting blood. Variance components– based quantitative genetic analyses were performed using SOLAR. All phenotypes except diastolic blood pressure were significantly heritable. Consistent with the definition of metabolic syndrome, many phenotypes exhibited significant environmental correlation, and significant genetic correlations were found between measures of adiposity and fasting glucose and

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