Apolipoprotein E Polymorphism Is Related to Plasma Lipids and Apolipoproteins in Mexican Adolescents

Document Type

Article

Authors

Aida X. Medina-Urrutia, Departamento de Endocrinologı´a, Instituto Nacional de Cardiologı´a Ignacio Cha´vez, Juan Badiano No. 1, Tlalpan, Mexico City 14080, Mexico.
Guillermo C. Cardoso-Saldaña, Departamento de Endocrinologı´a, Instituto Nacional de Cardiologı´a Ignacio Cha´vez, Juan Badiano No. 1, Tlalpan, Mexico City 14080, Mexico.
José Zamora-González, Departamento de Endocrinologı´a, Instituto Nacional de Cardiologı´a Ignacio Cha´vez, Juan Badiano No. 1, Tlalpan, Mexico City 14080, Mexico.
Yamamoto K. Liria, Departamento de Salud Pu´blica, Facultad de Medicina, Universidad Nacional Auto´noma de Me´xico, Mexico City, Mexico.
Carlos Posadas-Romero, Departamento de Endocrinologı´a, Instituto Nacional de Cardiologı´a Ignacio Cha´vez, Juan Badiano No. 1, Tlalpan, Mexico City 14080, Mexico.

Abstract

Previous studies in the Mexican population have failed to show an effect of apolipoprotein E (APOE) polymorphism on the lipid profile. The purpose of the present study was to determine the frequencies of APOE phenotypes, and their influence on lipid and apolipoprotein levels in a random sample of Mexican adolescents living in Mexico City. APOE polymorphism, fasting insulin levels, lipid levels, and apolipoprotein levels were determined in 420 adolescents. We found a high frequency of APOE*3 subjects (89.5%) and a low frequency of APOE*2 (3.0%) and APOE*4 (7.5%) subjects. The APOE*4 subjects (including APOE 4,3 and APOE 4,4) showed the highest concentrations of total cholesterol, low-density lipoprotein cholesterol, and apoB and the lowest high-density lipoprotein cholesterol levels, whereas carriers of the APOE*2 allele (APOE 3,2 and APOE 2,2) had the lowest values for total and low-density lipoprotein cholesterol and the highest concentrations of high-density lipoprotein cholesterol. No significant differences in triglyceride and insulin levels among subjects with different APOE polymorphisms were observed. Unlike previous studies in the Mexican population, our results show that lipid and lipoprotein levels are under the influence of APOE polymorphism. As in whites, APOE*4 may be a cardiovascular risk factor in the Mexican population.

Recommended Citation

Medina-Urrutia, Aida X.; Cardoso-Saldaña, Guillermo C.; Zamora-González, José; Liria, Yamamoto K.; and Posadas-Romero, Carlos (2004) "Apolipoprotein E Polymorphism Is Related to Plasma Lipids and Apolipoproteins in Mexican Adolescents," Human Biology: Vol. 76: Iss. 4, Article 8.
Available at: https://digitalcommons.wayne.edu/humbiol/vol76/iss4/8