Characterization of Admixture in an Urban Sample from Buenos Aires, Argentina, Using Uniparentally and Biparentally Inherited Genetic Markers

Document Type

Article

Authors

Verónica L. Martínex Marignac, Multidisciplinary Institute of Cell Biology, Department of Population Molecular Genetics, Calle 526 e/10 y 11, C.C. 403, La Plata, C.P. 1900, Buenos Aires, Argentina., Department of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Rd. North, Room 4019, South Building, Mississauga, ON L5L 1C6, Canada.
Bernardo Bertoni, Department of Genetics, College of Medicine, Universidad de la Repu ́blica, Avda. Gral. Flores 2125, C.P. 11800, Montevideo, Uruguay.
Esteban J. Parra, Department of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Rd. North, Room 4019, South Building, Mississauga, ON L5L 1C6, Canada.
Néstor O. Bianchi, Multidisciplinary Institute of Cell Biology, Department of Population Molecular Genetics, Calle 526 e/10 y 11, C.C. 403, La Plata, C.P. 1900, Buenos Aires, Argentina.

Abstract

In this study we analyzed a sample of the urban population of La Plata, Argentina, using 17 mtDNA haplogroups, the DYS199 Y-chromo- some polymorphism, and 5 autosomal population-associated alleles (PAAs). The contribution of native American maternal lineages to the population of La Plata was estimated as 45.6%, whereas the paternal contribution was much lower (10.6%), clearly indicating directional mating. Regarding auto- somal evidence of admixture, the relative European, native American, and West African genetic contributions to the gene pool of La Plata were esti- mated to be 67.55% (�2.7), 25.9% (�4.3), and 6.5% (�6.4), respectively. When admixture was calculated at the individual level, we found a low corre- lation between the ancestral contribution estimated with uniparental lineages and autosomal markers. Most of the individuals from La Plata with a native American mtDNA haplogroup or the DYS199*T native American allele show a genetic contribution at the autosomal level that can be traced primar- ily to Europe. The results of this study emphasize the need to use both uni- parentally and biparentally inherited genetic markers to understand the history of admixed populations.

Recommended Citation

Marignac, Verónica L. Martínex; Bertoni, Bernardo; Parra, Esteban J.; and Bianchi, Néstor O. (2004) "Characterization of Admixture in an Urban Sample from Buenos Aires, Argentina, Using Uniparentally and Biparentally Inherited Genetic Markers," Human Biology: Vol. 76: Iss. 4, Article 4.
Available at: https://digitalcommons.wayne.edu/humbiol/vol76/iss4/4