Frequency of the 35delG Mutation in the GJB2 Gene in Samples of European, Asian, and African Brazilians

Document Type

Article

Authors

C A. Oliveira, Universidade Estadual de CampinasFollow
F Alexandrino, Universidade Estadual de Campinas
K Abe-Sandes, University of Sao Paulo
W A. Silva, Jr., University of Sao Paulo

Abstract

Mutations in the GJB2 gene are a major cause of congenital deafness. One specific mutation, the 35delG mutation, has accounted for most of the GJB2 mutations detected in European populations and is one of the most frequent disease mutations identified so far. We evaluated the frequency of the 35delG mutation in DNA samples from Brazilians of European, Asian, and African ancestry. All DNA samples were screened for the 35delG mutation using an allele-specific PCR. This study shows that the frequency of a common mutation (35delG) is significantly lower in non-European populations.

Recommended Citation

Oliveira, C A.; Alexandrino, F; Abe-Sandes, K; and Silva, Jr., W A. (2004) "Frequency of the 35delG Mutation in the GJB2 Gene in Samples of European, Asian, and African Brazilians," Human Biology: Vol. 76: Iss. 2, Article 11.
Available at: https://digitalcommons.wayne.edu/humbiol/vol76/iss2/11