Lack of Arg972 Polymorphism in the IRS1 Gene in Parakana ̃ Brazilian Indians

Document Type

Article

Authors

Rosâgela M.N. Bezerra, Departamento de Cl ́ınica Me ́dica, FCM–UNICAMP, Campinas, SP, Brazil 13081-970.
Thiago T. Chadid, Departamento de Cl ́ınica Me ́dica, FCM–UNICAMP, Campinas, SP, Brazil 13081-970.
Claúdia M. Altemani, Departamento de Cl ́ınica Me ́dica, FCM–UNICAMP, Campinas, SP, Brazil 13081-970.
Teresa S.I. Sales, Departamento de Cl ́ınica Me ́dica, FCM–UNICAMP, Campinas, SP, Brazil 13081-970.
Taimundo Menezes, Instituto Evandro Chagas, Bele ́m, PA, Brazil.
Manoel C.P. Soares, Instituto Evandro Chagas, Bele ́m, PA, Brazil.
Sara T.O. Saad, Departamento de Cl ́ınica Me ́dica, FCM–UNICAMP, Campinas, SP, Brazil 13081-970.
Mario J.A. Saad, Departamento de Cl ́ınica Me ́dica, FCM–UNICAMP, Campinas, SP, Brazil 13081-970.

Abstract

Several polymorphisms in the insulin receptor substrate-1 (IRS1) gene have been reported in the last years. The most common IRS1 variant, a Gly VArg substitution at codon 972 (Arg972 IRS1), is more prev- alent among subjects who have features of insulin resistance syndrome asso- ciated, or not, with type 2 diabetes in European populations. To determine whether the absence of IRS1 polymorphism is a more general characteristic of Paleo-Indian-derived populations, we examined the Arg972 IRS1 poly- morphism in Parakana ̃ Indians and found a lack of this polymorphism in the Parakana ̃ population.

Recommended Citation

Bezerra, Rosâgela M.N.; Chadid, Thiago T.; Altemani, Claúdia M.; Sales, Teresa S.I.; Menezes, Taimundo; Soares, Manoel C.P.; Saad, Sara T.O.; and Saad, Mario J.A. (2004) "Lack of Arg972 Polymorphism in the IRS1 Gene in Parakana ̃ Brazilian Indians," Human Biology: Vol. 76: Iss. 1, Article 9.
Available at: https://digitalcommons.wayne.edu/humbiol/vol76/iss1/9