The Genetics of Obesity in Mexican Americans: The Evidence from Genome Scanning Efforts in the San Antonio Family Heart Study

Document Type

Article

Authors

Anthony G. Comuzzie, Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245.
Braxton D. Mitchell, Division of Diabetes, Obesity, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201.
Shelley Cole, Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245.
Lisa J. Martin, Center for Epidemiology and Biostatistics and The Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229.
Wen-Chi Hsueh, Department of Medicine, University of California San Francisco School of Medicine, UCSF Coordinating Center, San Francisco, CA 94105.
David L. Rainwater, Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245.
Laura Almasy, Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245.
Michael P. Stern, Division of Clinical Epidemiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245.
James Hixson, Human Genetics Center, School of Public Health, University of Texas Houston Health Science Center, Houston, Texas 77225.
Jean W. Maccluer, Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245.
John Blangero, Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245.

Abstract

Recent estimates indicate that approximately 18% of the population in the United States can be considered obese (defined as a body mass index [BMI] ≥ 30), and this rate is even higher among ethnic populations such as Mexican Americans. This figure becomes very significant given the strong evidence for obesity as a major risk factor for a variety of chronic diseases including type 2 diabetes mellitus and coronary heart disease. The search for genes involved in the expression of obesity has been one of the focal points of the San Antonio Family Heart Study (SAFHS), a large, familybased study to examine the genetics of risk for atherosclerosis in Mexican Americans. To date, our genome scanning effort has reported two quantitative trait loci (QTLs) with pronounced effects on the expression of a variety of obesity—related phenotypes (e.g., leptin levels, fat mass, and BMI) located on chromosomes 2 and 8. We are currently working to further refine these signals and to identify the genes and allelic variants involved. Here, we summarize the latest results from our ongoing efforts to identify obesity genes in the San Antonio Family Heart Study.

Recommended Citation

Comuzzie, Anthony G.; Mitchell, Braxton D.; Cole, Shelley; Martin, Lisa J.; Hsueh, Wen-Chi; Rainwater, David L.; Almasy, Laura; Stern, Michael P.; Hixson, James; Maccluer, Jean W.; and Blangero, John (2003) "The Genetics of Obesity in Mexican Americans: The Evidence from Genome Scanning Efforts in the San Antonio Family Heart Study," Human Biology: Vol. 75: Iss. 5, Article 1.
Available at: https://digitalcommons.wayne.edu/humbiol/vol75/iss5/1