Association of Vitamin D Receptor Polymorphisms with Osteoporosis in Mexican Postmenopausal Women

Document Type

Article

Authors

Rubén Lisker, Department of Genetics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan 14000, D.F. México.
María A. López, Department of Genetics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan 14000, D.F. México.
Salomón Jasqui, Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan 14000, D.F. México.
Sergio Ponce De Leon Rosales, Department of Clinical Epidemiology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan 14000, D.F. México.
Ricardo Correa-Rotter, Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan 14000, D.F. México.
Sergio Sánchez, Blood Bank, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan 14000, D.F. México.
Osvaldo M. Mutchinick, Department of Genetics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan 14000, D.F. México.

Abstract

It has been reported that Vitamin D receptor polymorphisms are associated with osteoporosis, particularly those demonstrated by the BsmI and FokI restriction enzymes. Herein we report the results of a case-control study performed in postmenopausal Mexican women. We studied 65 osteoporotic women (≤ –2.5 SD bone mineral density [BMD] of young normal females) and 57 controls (over 90% ≥ –1.5 SD BMD of young normal females. Restriction enzymes BsmI and FokI were used to identify polymorphisms. Odds ratios and their 95% confidence intervals were calculated, and analysis was performed controlling for age as a covariate. The BsmI genotypes revealed a higher frequency of the bb genotype in cases than in controls, contradicting much of the literature that suggests this genotype protects females against osteoporosis. Regarding the FokI genotypes, we were unable to confirm that the FF genotype has a protective effect against osteoporosis. The inconsistencies found in the literature and the results obtained in the present work suggest to us that other genetic and nongenetic factors are involved in the occurrence of osteoporosis, confounding the results of the possible association of osteoporosis and VDR polymorphisms.

Recommended Citation

Lisker, Rubén; López, María A.; Jasqui, Salomón; Rosales, Sergio Ponce De Leon; Correa-Rotter, Ricardo; Sánchez, Sergio; and Mutchinick, Osvaldo M. (2003) "Association of Vitamin D Receptor Polymorphisms with Osteoporosis in Mexican Postmenopausal Women," Human Biology: Vol. 75: Iss. 3, Article 8.
Available at: https://digitalcommons.wayne.edu/humbiol/vol75/iss3/8