Endothelial Nitric Oxide Synthase Gene Polymorphism in the Indian and Mestizo Populations of Mexico

Document Type

Article

Authors

Haydée Rosas-Vargas, Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, México, D.F., México.
Adrían Flores-Segura, Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, México, D.F., México.
Boris Guizada-Claure, Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, México, D.F., México.
Gilberto Vargas-Alacón, Departamento de Biología Celular, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F., México.
Julio Granados, Departamento de Inmunología y Reumatología, Instituto Nacional de la Nutrición Salvador Zubirán, México, D.F., México.
Fabio Salamanca, Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, México, D.F., México.
Ramón Coral-Vázquez, Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, México, D.F., México.

Abstract

Endothelium-derived nitric oxide (NO) is an important factor in vasodilation synthesized by endothelial nitric oxide synthase (eNOS). A polymorphism (894 G to T) in exon 7 of the eNOS gene causes the conversion of Glu to Asp in position 298. The Glu298Asp polymorphism has been extensively associated with cardiovascular disease. We determined the Glu298Asp polymorphism frequency in healthy Mexican Mestizo, Huastec, Mayo, and Mayan populations by the endonuclease restriction method. The four populations analyzed were in Hardy-Weinberg equilibrium. Allele frequencies were similar among Mexican populations but different when compared with Caucasians. However, when compared with allele frequencies in Asian populations, Mestizo and Huastec allele frequencies were significantly different. Genotypically, only the Mestizos presented Asp298 homozygosity. The absence of double mutants in Indian populations resembles that in Asians. With these data, we conclude that the low frequency of the eNOS Glu298Asp polymorphism in Indian and Mestizo populations of Mexico is related to the Asian origin of Amerindian groups.

Recommended Citation

Rosas-Vargas, Haydée; Flores-Segura, Adrían; Guizada-Claure, Boris; Vargas-Alacón, Gilberto; Granados, Julio; Salamanca, Fabio; and Coral-Vázquez, Ramón (2003) "Endothelial Nitric Oxide Synthase Gene Polymorphism in the Indian and Mestizo Populations of Mexico," Human Biology: Vol. 75: Iss. 1, Article 8.
Available at: https://digitalcommons.wayne.edu/humbiol/vol75/iss1/8