Mode of Inheritance of Hand Osteoarthritis in Ethnically Homogeneous Pedigrees

Document Type

Article

Authors

Gregory Livshits, Research Unit, Human Population Biology, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Leonid Kalichman, Research Unit, Human Population Biology, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Zvi Cohen, Department of Traumatology and Orthopedic Surgery “A,” Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Eugene Kobyliansky, Research Unit, Human Population Biology, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Abstract

The aim of the present study was to investigate the extent and mode of inheritance of hand osteoarthritis (OA) using a large sample of ethnically homogeneous pedigrees. Two types of segregation analysis (SA) models were examined. Type I models used the data adjusted for potential significant covariates, particularly age and sex, prior to genetic analysis. Type II models incorporated effects of the potential covariates into major gene penetrance functions, permitting an account of the genotype covariate-specific effect on study variables. The results of this study strongly supported the hypothesis of a major gene effect and additional multifactorial component. The best-fitting model was the Mendelian one with an additive type of inheritance. The estimates obtained using the standard three-factor variance decomposition analysis suggest that age (72.8%) and major gene (14.5%) are the main sources of interindividual differences in the development of hand OA. The contribution of the putative major gene on age- and sex-adjusted OA phenotype variation was 55% in the present study.

Recommended Citation

Livshits, Gregory; Kalichman, Leonid; Cohen, Zvi; and Kobyliansky, Eugene (2002) "Mode of Inheritance of Hand Osteoarthritis in Ethnically Homogeneous Pedigrees," Human Biology: Vol. 74: Iss. 6, Article 7.
Available at: https://digitalcommons.wayne.edu/humbiol/vol74/iss6/7