Allele Frequencies of Apolipoprotein E Gene Polymorphisms in the Protein Coding Region and Promoter Region (-491A/T) in a Healthy Norwegian Population

Document Type

Article

Authors

Theresa Kumar, Department of Pathology, Ullevål Hospital, Oslo, Norway.
Knut Liestøl, Department of Informatics, University of Oslo, Oslo, Norway.
Jan Mæhlen, Department of Pathology, Ullevål Hospital, Oslo, Norway.
Aksel Hiorth, Department of Physics, University of Oslo, Oslo, Norway.
Espen Jettestuen, Department of Physics, University of Oslo, Oslo, Norway.
Helge Lind, Department of Pathology, Ullevål Hospital, Oslo, Norway.
Sverre-Henning Brorson, Department of Pathology, Ullevål Hospital, Oslo, Norway.

Abstract

This study examines the distribution of apolipoprotein E (APOE) alleles in a population of healthy male and female Norwegians (n = 798) below the age of 40. The -491A/T polymorphism of the promoter region of the APOE gene was also examined. A seminested polymerase chain reaction was applied in the genotyping. The results showed that the E3 allele had the highest frequency (0.744), followed by E4 (0.198) and E2 (0.058). The APOE frequencies found in this study differ significantly from those obtained in earlier Norwegian APOE phenotypings. The allele frequencies in the -491 site of the promoter region were 0.845 for the A allele and 0.155 for the T allele. The genotype frequency was highest for AA (0.707), followed by AT (0.277) and TT (0.016). Moreover, the A allele was in linkage disequilibrium to E4.

Recommended Citation

Kumar, Theresa; Liestøl, Knut; Mæhlen, Jan; Hiorth, Aksel; Jettestuen, Espen; Lind, Helge; and Brorson, Sverre-Henning (2002) "Allele Frequencies of Apolipoprotein E Gene Polymorphisms in the Protein Coding Region and Promoter Region (-491A/T) in a Healthy Norwegian Population," Human Biology: Vol. 74: Iss. 1, Article 10.
Available at: https://digitalcommons.wayne.edu/humbiol/vol74/iss1/10