Brief Communications Geographical North-South Decline in DNASE! *2 in Japanese Populations

Document Type

Article

Authors

Haruo Takeshita, Gunma University School of Medicine
Toshihiro Yasuda, Gunma University School of Medicine
Yoshimitsu Nakashima, Gunma University School of Medicine
Kouichi Mogi, Gunma University School of Medicine
Koichiro Kishi, Gunma University School of Medicine
Hiroshi Shiono, Asahikawa Medical College
Karou Sagisaka, Tokyo Medical Examiner's Office
Isao Yuasa, Tottori University Faculty of Medicine
Hiroaki Nishimukai, Ehime University
Hiroshi Kimura, Kurume University School of Medicine

Abstract

Allele frequencies for human deoxyribonuclease I (DNase I) phenotypes were determined using blood samples from about 2000 Japanese subjects living in nine prefectures, and compared with one another. DNase I phenotyping was performed principally using isoelectric focusing electrophoresis and activity staining. The DNase I system was shown to have enhanced potential for anthropologic, genetic, and clinical studies of Japanese populations. DNase I phenotypes were analyzed to evaluate the degree of genetic variation at the DNASE1 locus. Our examination of DNase I types revealed a decreasing north-ta-south gradient in the DNASE1 allele.

Recommended Citation

Takeshita, Haruo; Yasuda, Toshihiro; Nakashima, Yoshimitsu; Mogi, Kouichi; Kishi, Koichiro; Shiono, Hiroshi; Sagisaka, Karou; Yuasa, Isao; Nishimukai, Hiroaki; and Kimura, Hiroshi (2001) "Brief Communications Geographical North-South Decline in DNASE! *2 in Japanese Populations," Human Biology: Vol. 73: Iss. 1, Article 9.
Available at: https://digitalcommons.wayne.edu/humbiol/vol73/iss1/9