Adenosine Deaminase Polymorphisms at the Protein and DNA Levels

Document Type

Brief Communication

Authors

Fátima Santos, Universidade do Porto; Faculdade de Ciências da Universidade do Porto, Praca Gomes Teixeira
António Amorim, Universidade do Porto; Faculdade de Ciências da Universidade do Porto, Praca Gomes Teixeira
Jorge Rocha, Universidade do Porto; Faculdade de Ciências da Universidade do Porto, Praca Gomes Teixeira
Jost Kömpf, Eberhard-Karls Universität

Abstract

Adenosine deaminase {ADA, E.C. 3.5.4.4) exhibits a wellknown polymorphism at the protein level. We have studied ADA and an STR polymorphism exhibiting variation of a TTTA repeat motif at intron 3 of the ADA gene in random samples from northern Portugal (N = 218) and southwestern Germany {N = 114). The ADA phenotype distribution and population data on the worldwide distribution of ADA favor recurrent mutation as an explanation for the maintenance of the ADA *2 gene product at polymorphic frequencies.

Recommended Citation

Santos, Fátima; Amorim, António; Rocha, Jorge; and Kömpf, Jost (1999) "Adenosine Deaminase Polymorphisms at the Protein and DNA Levels," Human Biology: Vol. 71: Iss. 6, Article 10.
Available at: https://digitalcommons.wayne.edu/humbiol/vol71/iss6/10