Some Atypical and Rare Sickle Cell Gene Haplotypes in Populations of Andhra Pradesh, India

Document Type

Article

Authors

Y. Niranjan, Andhra University; Centre for DNA Fingerprinting and Diagnostics, Centre for Cellular and Molecular Biology Campus
G.R. Chandak, Centre for DNA Fingerprinting and Diagnostics, Centre for Cellular and Molecular Biology Campus
P. Veerraju, Andhra University
Lalji Singh, Centre for DNA Fingerprinting and Diagnostics, Centre for Cellular and molecular Biology Campus

Abstract

We have investigated the clinical, hematological, and molecular genetic characteristics of sickle cell anemia patients from 6 populations of Andhra Pradesh, South India. Of 72 sickle cell chromosomes (HBB*S) 60 belong to characteristic Arab-Indian haplotypes, 6 to variant Arab-Indian haplotypes, 1 to a Bantu haplotype, 2 to a Cameroon haplotype, and 3 to rare haplotypes. This is the first report of a Bantu haplotype in an Indian population. Some information on haplotype characteristics of normal chromosomes (HBB*A) is also presented. The average hemoglobin level was 7.3 g% and mean fetal hemoglobin (HbF) level was 12.6%. The higher HbF levels corroborate earlier observations in sickle cell homozygotes from India. Clinical investigations have revealed splenomegaly and painful crises as the most common features in these patients.

Recommended Citation

Niranjan, Y.; Chandak, G.R.; Veerraju, P.; and Singh, Lalji (1999) "Some Atypical and Rare Sickle Cell Gene Haplotypes in Populations of Andhra Pradesh, India," Human Biology: Vol. 71: Iss. 3, Article 2.
Available at: https://digitalcommons.wayne.edu/humbiol/vol71/iss3/2