Novel (CA)n Marker DXYS241 on the Nonrecombinant Part of the Human Y Chromosome

Document Type

Article

Authors

Svetlana E. Kotliarova, University of Tokyo; Institute of Molecular Pathology and Ecological Biochemistry
Tatsushi Toda, University of Tokyo
Osamu Takenaka, Kyoto University
Ikumi Matsushita, University of Tokyo
Akiko Hida, University of Tokyo
Toshikatsu Shinka, University of Tokyo
Jun Goto, University of Tokyo
Katsushi Tokunaga, University of Tokyo
Yasuo Nakagome, University of Tokyo
Tutaka Nakahori, University of Tokyo; University of Tokushima

Abstract

The origin of modem humans can be traced by comparing polymorphic sites in either mitochondria or genomic sequences between humans and other primates. The human Y chromosome has both a nonrecombining region and X-Y homologous pseudo-autosomal regions. In the nonrecombining region events during evolution can be directly detected. At least a part of homology between Xq21 and Y p l l is a result of rather recent translocations from the X chromosome to the Y chromosome. DNA markers residing in the nonrecombining region of the human Y chromosome are potentially useful in tracing male-specific gene flow in human evolution. However, the number of available markers in the region is limited. Here, we report a novel X-Y homologous (CA)„ repeat locus in the nonrecombining region of the Y chromosome. This marker, DXYS241, has several interesting features. Y- and X-chromosome alleles are distinguishable because the Y-chromosome alleles are shorter than the X-chromosome alleles most of the time. We developed 2 primer sets for specific examination of Y- and X-chromosome alleles. The marker should be useful in establishing relationships between populations based on patrilineal gene flow. Sequences homologous to DXYS241 are also found on the X chromosome of primates. Four events during primate evolution that led to the modem human Y chromosome were identified.

Recommended Citation

Kotliarova, Svetlana E.; Toda, Tatsushi; Takenaka, Osamu; Matsushita, Ikumi; Hida, Akiko; Shinka, Toshikatsu; Goto, Jun; Tokunaga, Katsushi; Nakagome, Yasuo; and Nakahori, Tutaka (1999) "Novel (CA)n Marker DXYS241 on the Nonrecombinant Part of the Human Y Chromosome," Human Biology: Vol. 71: Iss. 2, Article 8.
Available at: https://digitalcommons.wayne.edu/humbiol/vol71/iss2/8