Twenty-Seven Base Pair Deletion in Erythrocyte Band 3 Protein Gene Responsible for Southeast Asian Ovalocytosis Is Not Common among Southeast Asians

Document Type

Article

Authors

Masako Kimura, University of Tokyo
Yuko Shimizu, University of Tokyo
Wannapa Settheetham-Ishida, Khon Kaen University
Augustinus Soemantri, Diponegoro University
Danai Tiwawech, Research Division, National Cancer Institute, Bangkok, Thailand
Amornrat Romphruk, Khon Kaen University
Phaibool Duangchan, Srinakharinwirot University
Takafumi Ishida, University of Tokyo

Abstract

Screening for a 27-bp deletion in the band 3 protein gene that causes Southeast Asian/Melanesian ovalocytosis (SAO) was carried out using the PCR method among 15 Southeast Asian populations of Thailand (Akha, Hmong, Isaan, Red Karen, White Karen, Black Lahu, Lisu, Manni, Shan, and central Thais) and Indonesia (Bugis, Dayak, Javanese, Madurian, and Toraja). Individuals with the 27-bp deletion were identified only in the Bugis of southern Sulawesi, the Dayak of southern Borneo, and Javanese of central Java. The gene frequency of the 27-bp deletion in the general population was rather low: 0.012 and 0.013 in the Dayak and the Bugis, respectively. This restricted ethnic and geographic distribution of the 27-bp deletion suggests (1) local differentiation in the prevalence of this deletion in a given ethnic group and (2) the presence of molecular heterogeneity of SAO.

Recommended Citation

Kimura, Masako; Shimizu, Yuko; Settheetham-Ishida, Wannapa; Soemantri, Augustinus; Tiwawech, Danai; Romphruk, Amornrat; Duangchan, Phaibool; and Ishida, Takafumi (1998) "Twenty-Seven Base Pair Deletion in Erythrocyte Band 3 Protein Gene Responsible for Southeast Asian Ovalocytosis Is Not Common among Southeast Asians," Human Biology: Vol. 70: Iss. 6, Article 2.
Available at: https://digitalcommons.wayne.edu/humbiol/vol70/iss6/2